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Luteolin also blocks cell proliferation, hinders cell cycle progression, and triggers apoptosis within 24 and 48 h of analysis [79]

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857 For example, it is not clear whether normal homeostasis and cell signaling involving these or other metals are altered upon overload with vanadium and chromium or whether this overload directly promotes undesired reactions contributing to the disease such as oxidative stress, altered mitochondrial metabolism or mutations in genomic DNA